The Brain Melanocortin System, Sympathetic Control, and Obesity Hypertension
نویسندگان
چکیده
منابع مشابه
The brain melanocortin system, sympathetic control, and obesity hypertension.
Excess weight gain is the most significant, preventable cause of increased blood pressure (BP) in patients with primary (essential) hypertension and increases the risk for cardiovascular and renal diseases. In this review, we discuss the role of the brain melanocortin system in causing increased sympathetic activity in obesity and other forms of hypertension. In addition, we highlight potential...
متن کاملRole of sympathetic nervous system and neuropeptides in obesity hypertension.
Obesity is the most common cause of human essential hypertension in most industrialized countries. Although the precise mechanisms of obesity hypertension are not fully understood, considerable evidence suggests that excess renal sodium reabsorption and a hypertensive shift of pressure natriuresis play a major role. Sympathetic activation appears to mediate at least part of the obesity-induced ...
متن کاملMechanisms underlying hypertension and obesity: a melanocortin linkage in the brain.
Hypertension significantly contributes to cardiovascular disease, renal dysfunction and stroke, and it greatly enhances diabetes-related morbidity and mortality. Despite these significant interactions, research has yet to fully elucidate the underlying mechanisms. Elevated sympathetic nervous system activity appears to contribute to many forms of the disease, but it is unclear which factors lea...
متن کاملThe sympathetic system and hypertension.
Measurement of regional sympathetic activity in lean essential hypertension patients using electrophysiologic (sympathetic nerve recording) and neurochemical (measurement of norepinephrine spillover) techniques demonstrates activation of sympathetic outflow to the heart, kidneys, and skeletal muscle vasculature in younger (< 45 years) patients. The increase in sympathetic activity is a mechanis...
متن کاملInteractions between the melanocortin system and leptin in control of sympathetic nerve traffic.
Leptin plays an important role in regulation of body weight through regulation of food intake and sympathetically mediated thermogenesis. The hypothalamic melanocortin system, via activation of the melanocortin-4 receptor (MC4-R), decreases appetite and weight, but its effects on sympathetic nerve activity (SNA) are unknown. In addition, it is not known whether sympathoactivation to leptin is m...
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ژورنال
عنوان ژورنال: Physiology
سال: 2014
ISSN: 1548-9213,1548-9221
DOI: 10.1152/physiol.00061.2013